Animal Models for Development of Cancer Immunotherapy

Animal Models for the Development of Cancer Immunotherapy

Provides  readers with a clear understanding of the value and challenges of using  common and emerging preclinical models in cancer immunotherapy research  and development.

Animal models are essential tools  for studying a range of issues in preclinical and clinical research on  therapies targeting cancerous tumors. As clinical trials of advances in  cancer immunotherapy are predicted to outpace preclinical research in  the near future, there remains an urgent need to develop better animal  models for preclinical evaluation of novel modulators. Animal Models for the Development of Cancer Immunotherapy provides a detailed overview of different preclinical model systems for  development of novel cancer immunotherapies while highlighting how key  aspects of individual models translate into clinical findings. 

Covering  the introduction, development, and therapeutic applications of animal  models for cancer immunotherapy, this comprehensive volume helps  pharmacologists identify suitable animal models, design pharmacological  or translational studies, and advance their mechanistic understanding of  therapeutic agents, and increase the possibility of success for novel  immunotherapies in clinical settings. Chapters written by prominent  leaders in the field address specific models that evaluate  immuno-oncology drugs are supported by in-depth case studies and  extensive references throughout. 

• Emphasizes  the importance of modeling tumor metastasis in preclinical models for  efficient translation of findings into the clinic
• Explores recently discovered mechanisms of resistance and their preclinical modeling
• Highlights the unique characteristics and features of autologous and allogeneic approaches for humanization of mouse models
• Reviews  development of bone marrow-liver-thymus (BLT) immune humanized mice and  emerging alternative models such as genetically engineered mouse models  (GEMM)
• Discusses alternative animal models for cancer research such as severe combined immunodeficiency (SCID) pigs

Animal Models for the Development of Cancer Immunotherapy is an essential resource for scientists and researchers in the  pharmaceutical and biotechnology industries, medicinal chemists and  biochemists, cell and molecular biologists, pharmacologists,  immunologists, and clinicians.