In the name of Allah the Merciful

Drug Transporters: Molecular Characterization and Role in Drug Disposition

Guofeng You, Marilyn E. Morris, 1119737559, 9781119737551, 978-1119737551

English | 2022 | PDF

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Drug transporter fundamentals and relevant principles and techniques, featuring new and expanded chapters

Drug  Transporters: Molecular Characterization and Role in Drug Disposition  provides in-depth analysis of the conceptual evolution and technical  development for studying drug transporters. Contributions by an  international panel of leading researchers address advances in  transporters as drug targets, transporters in pharmacotherapy, the  impact of transporters on drug efficacy and safety, the development of  sophisticated model systems and sensitive assay methods, and more.  Divided into two parts, the book first provides a thorough overview of  relevant drug transporters before detailing the principles of drug  transport and associated techniques.

The updated and expanded  third edition includes new chapters on in vitro-in vivo scale-up of drug  transport activities, the ontogeny of drug transporters, the  application of physiologically-based pharmacokinetic and pharmacodynamic  modeling, and the use of transporters as therapeutic targets for  diseases.
Reflects the current state of the field and offers  perspectives on future directions. Covers basic knowledge, clinical  outcomes, and emerging discoveries in transporter science. Provides  up-to-date information on drug transporter families, mechanisms, and  clinical implicationsIncludes extensive references and numerous figures  and tables throughout
Understandable for novices while offering  sufficient depth for more experienced researchers, Drug Transporters:  Molecular Characterization and Role in Drug Disposition, Third Edition  is an excellent textbook for pharmacological or physiological science  courses in drug/membrane transport, and an invaluable reference for  academic or industrial scientists working in the transporter field and  related areas of drug metabolism, pharmacokinetics, and  pharmacodynamics.