This book, Manual of Heart Failure, deals with heart failure. Heart failure is pandemic amongst industrialized nations. It is a disease with stark implications, markedly reducing life-expectancy and diminishing the quality of life. This book has been designed for the readers seeking a comprehensive overview of all aspects of the disease entity. The chapters have been organized in such a way that all the aspects of heart failure are covered. The initial chapters discuss the global burden of heart failure and the challenges involved in diagnosing it. A special emphasis on systolic and diastolic heart failure has been made highlighting its pathophysiology, diagnosis, and therapeutic options. The final chapters discuss the major challenges involved in treating people with end-stage heart failure with advanced cardiac therapies, including cardiac transplantation and mechanical circulatory support.