Modeling and simulation (M&S) based systems engineering (MSBSE) is the extension of MBSE, which enhances the value of MBSE and the ability of digitally evaluating and optimizing the whole system through comprehensive applications of M&S technologies. This book puts together the recent research in MSBSE, and hopefully this will provide the researchers and engineers with reference cases in M&S technologies to support the R&D of complex products and systems.