In the name of Allah the Merciful

Textbook of Ion Channels Volume III: Regulation, Physiology, and Diseases

Jie Zheng, Matthew C. Trudeau, 0367538199, 978-0367538194, 9780367538194, B0C79NYGHF

English | 2023 | PDF

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The Textbook of Ion Channels is  a set of three volumes that provides a wide-ranging reference source on  ion channels for students, instructors and researchers. Ion channels  are mem- brane proteins that control the electrical properties of  neurons and cardiac cells; medi- ate the detection and response to  sensory stimuli like light, sound, odor, and taste; and regulate the  response to physical stimuli like temperature and pressure. In  non-excitable tissues, ion channels are instrumental for the regulation  of basic salt balance that is critical for homeostasis. Ion channels are  located at the surface membrane of cells, giving them the unique  ability to communicate with the environment, as well as the membrane of  intracellular organelles, allowing them to regulate internal  homeostasis. Ion channels are fundamentally important for human health  and diseases, and are important targets for pharmaceuticals in mental  illness, heart disease, anesthesia, pain and other clinical appli-  cations. The modern methods used in their study are powerful and  diverse, ranging from single ion-channel measurement techniques to  models of ion channel diseases in animals, and human clinical trials for  ion channel drugs.

Volume III  includes coverage of key ion channel regulators and their mechanisms,  the role of ion channels working in concert in selected physiological  systems, and examples of ion channel mutations and dysfunction in a  selection of diseases. Chapters on ion channel regulation include splice  variants, calcium–calmodulin regulation, regulation by G pro- teins,  and lipids. A selection of ion channels in physiological systems  includes ion chan- nels of the heart, ion channels in immune cells and  their role in pancreatic beta cells and regulation of insulin secretion,  and the role of channels in sperm and eggs. While disease mechanisms  are integrated into the chapters of Volume II, Volume III offers special  consid- eration of ion channels in epilepsy, cystic fibrosis and pain  syndromes.

All three volumes give  the reader an introduction to fundamental concepts needed to understand  the mechanism of ion channels, a guide to the technical aspects of ion  channel research, offer a modern guide to the properties of major ion  channel families, and includecoverage of key examples of regulatory,  physiological, and disease roles for ion channels.