Bioreactors: Animal Cell Culture Control for Bioprocess Engineering

Bioreactors: Animal Cell Culture Control for Bioprocess Engineering  presents the design, fabrication, and control of a new type of  bioreactor meant especially for animal cell line culture. The new  bioreactor, called the "see-saw bioreactor," is ideal for the growth of  cells with a sensitive membrane. The see-saw bioreactor derives its name  from its principle of operation in which liquid columns in either limb  of the reactor alternately go up and down. The working volume of the  reactor is small, to within 15 L. However, it can easily be scaled up  for large production in volume of cell mass in the drug and  pharmaceutical industries.

The authors describe the principle of  operation of the see-saw bioreactor and how to automatically control the  bioprocess. They discuss different control strategies as well as the  thorough experimental research they conducted on this prototype  bioreactor in which they applied a time delay control for yield  maximization.

To give you a complete understanding of the design  and development of the see-saw bioreactor, the authors cover the  mathematical model they use to describe the kinetics of fermentation,  the genetic algorithms used for deriving the optimal time trajectories  of the bioprocess variables, and the corresponding control inputs for  maximizing the product yield. One chapter is devoted to the application  of time delay control. Following a description of the bioreactor’s  working setup in the laboratory, the authors sum up their investigation  and define the future scope of work in terms of design, control, and  software sensors.