Contemporary Accounts in Drug Discovery and Development

A useful guide for medicinal chemists and pharmaceutical scientists

Drug  discovery is a lengthy and complex process that typically involves  identifying an unmet medical need, determining a biological target,  chemical library screening to identify a lead, chemical optimization,  preclinical studies and clinical trials. This process often takes many  years to complete, and relies on practitioners’ knowledge of chemistry  and biology, but also—and perhaps more importantly—on experience.  Improving the success rate in discovery and development through a  thorough knowledge of drug discovery principles and advances in  technology is critical for advancement in the field.

Contemporary  Accounts in Drug Discovery and Development provides drug discovery  scientists with the knowledge they need to quickly gain mastery of the  drug discovery process. A thorough accounting is given for each drug  covered within the book, as the authors provide pharmacology, drug  metabolism, biology, drug development, and clinical studies for every  case, with modern drug discovery principles and technologies  incorporated throughout.

Contemporary Accounts in Drug Discovery and Development readers will also find
Case  histories used as an engaging way of learning about the drug  discovery/development processDetailed biological rational and background  information, drug design principles, SAR development, ADMET  considerations, and clinical studiesThe full history of individual  marketed small molecule drugsCoverage of drug candidates that have  passed Phase I clinical trials with different modalities, such as  antibody drug conjugates (ADC), proteolysis-targeting chimera (PROTAC),  and peptide drugsThe application of new technologies in drug discovery  such as DNA-encoded libraries (DEL), positron emission tomography (PET),  and physics-based computational modeling employing free energy  perturbation (FEP)
Contemporary Accounts in Drug Discovery and  Development is a helpful tool for medicinal chemists, organic chemists,  pharmacologists, and other scientists in drug research and process  development. It may be considered essential reading for graduate courses  in drug discovery, medicinal chemistry, drug synthesis, pharmaceutical  science, and pharmacology. It is also a useful resource for  pharmaceutical industry labs, as well as for libraries.