Drug Disposition and Pharmacokinetics: Principles and Applications for Medicine, Toxicology and Biotechnology

Drug Disposition and Pharmacokinetics
The most up-to-date edition of a leading reference in drug disposition and pharmacokinetics

In  this new, fully-revised edition of Drug Disposition and  Pharmacokinetics: Principles and Applications for Medicine, Toxicology  and Biotechnology the authors deliver an authoritative and comprehensive  discussion of the fate of drug molecules in the body, as well as its  implications for pharmacological and clinical effects. The text offers a  unique and balanced approach that combines discussion of the specific  physical and biological factors affecting the absorption, distribution,  metabolism, and excretion of drugs, with mathematical assessments of  plasma and body fluid concentrations. The book assumes little prior  knowledge and is an ideal reference for practicing professionals in  industry as well as researchers and academics.

This latest  edition provides readers with a new introductory chapter, as well as new  chapters covering monoclonal antibodies, the role of stereochemistry in  drug disposition and pharmacokinetics, DMPK in non-human species, and  the recent use of AI in drug development. Readers will also find:
Thorough introductions to drug disposition, pharmacokinetics, and  pharmacokinetic modeling In-depth treatments of the kinetics of drug  elimination and the relationship between concentration and effect,  including PK–PD modeling Comprehensive discussions of predictive  pharmacokinetics and the disposition of biological molecules, including  peptides and monoclonal antibodies Detailed examinations of the effects  of sex, pregnancy, age, and disease, as well as drug monitoring in  therapeutics and the use of AI in drug development and treatment
Perfect  for professionals and researchers working with the scientific aspects  of drug disposition in human and veterinary medicine, toxicology, and  pharmacology. Drug Disposition and Pharmacokinetics will earn a place in  the libraries of students of senior-level courses in pharmacy.