Oxidative Eustress in Exercise Physiology

Oxidative Eustress in Exercise Physiology unravels key physiological  responses and adaptations to different redox-regulated exercise  paradigms at the cell, tissue, and whole-body level in model systems and  humans in health and disease. While the mechanistic details are still  unclear, key intracellular redox indices seem to be dysregulated with  age. Consequently, beneficial molecular responses to acute endurance  exercise decline in older individuals. Recent research suggests that  manipulating mitochondrial redox homeostasis by supplementing with the  mitochondria-targeted coenzyme Q10 for six weeks markedly improves  physical function in older adults; i.e. it may be possible to maximise  the benefits of exercise by manipulating the redox environment. The  research described in this book suggests that significant translational  potential exists with respect to cardiovascular disease,  neurodegeneration and cancer. An international team of researchers  documents the importance of redox biology in health and disease,  especially when exercise is a clinically useful tool for the treatment  of many diseases and conditions.

Features
Defines essential redox biology reactions and concepts in exercise physiology
Assesses key redox parameters in an in vivo human exercise context
Identifies the challenges, opportunities and boundaries of current knowledge
Includes a critique of the underlying mechanisms
Summarises examples of translationally important research relating to disease states