Introduction to the physics of polarized light.- History of the application of polarized light.- Mueller Matrix instrumentation design for clinical applications.- Clinical applications of PS-OCT.- Mueller matrix analysis, decompositions and novel quantitative approaches to data analysis.- Single Scattering applications.- Polarized light Monte Carlo modeling.- Cancer staging with polarized light.- Polarized light and the skin.- Polarized light and the eye.- Polarized light and the brain.- Polarized light endoscopy.- Polarized light (Mueller Matrix) microscopy.- Confocal Mueller Matrix microscopy and hybrid systems.- Conclusions.