Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development

Practical Application of Supercritical Fluid Chromatography for  Pharmaceutical Research and Development provides a valuable “go-to”  reference for many difficult-to-solve challenges using pertinent  chromatographic theory, first-hand case studies, and examples provided  from academic and industry experts. This text also enables professors  teaching an analytical instrumental course to introduce and instruct  students about one of the most sustainable and powerful separation  methods currently available. While the text has broad applicability  across industrial sectors, it focuses primarily on application in the  pharmaceutical industry. The book is designed to allow readers to align  current HPLC/UHPLC capabilities with SFC as an orthogonal tool for  project specific methods in the pharmaceutical industry. It highlights  where SFC falls on the spectrum of useful chromatographic tools for  routine and challenging separative methods.

Experienced HPLC  users who are interested in developing knowledge in orthogonal  separation techniques, as well as newcomers to the field of separation  science, will find this text particularly useful. Chapters address where  SFC may fit the analytical needs of the pharmaceutical industry and  alert the readers as to where the technique will not fit. Readers will  gain an understanding of how and where SFC may be applied and adapted  more routinely across the pharmaceutical industry as a ‘green’ way of  undertaking separation opportunities and challenges. Areas within the  pharmaceutical industry include early drug discovery, process chemistry,  and late stage development and manufacturing.