Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective

Comprehensive resource on all aspects of protein homeostasis, covering  both historical perspectives and emerging technologies that are  revolutionizing the field

Protein Homeostasis in Drug Discovery  highlights drug discovery and development efforts targeting protein  homeostasis and considers the emerging appreciation that a protein’s  activity may not be the only factor to consider when developing  therapeutic agents.

The chapters cover various aspects of  protein homeostasis such as cellular localization, abundance,  interactions, and more. Moreover, the text contains up-to-date  information regarding targeted protein degradation, an emerging drug  discovery modality.

Readers interested in targeting different  regulatory events that control protein homeostasis or modulating protein  abundance will find this book an excellent resource. Furthermore, those  interested in the link between biological function and regulating  protein levels in living organisms, especially in the context of drug  discovery, will learn from numerous examples discussed in this book.

In Protein Homeostasis in Drug Discovery, readers can expect to find information on:
Protein  folding, quality control, pharmacology, and drug targeting processes  Recent advances in our understanding of protein homeostasis, covering  emerging technologies and opportunities for therapeutic intervention   Targeted protein degradation (TPD) and strategies such as PROTACs and  molecular glues, including a chapter on TPD as an antiviral drug  discovery strategy Drug discovery and development efforts aimed at  correcting, stabilizing, and rescuing proteins, with examples included  Advantages and key shortcomings of both phenotypic and target-based  traditional drug discovery methods
Collectively, Protein Homeostasis  in Drug Discovery offers the reader an opportunity to learn more about  the importance of considering and targeting protein homeostasis. The  text is a must-read resource for academics, professionals in the  pharmaceutical industry, and advanced students in various  science-related fields.